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Arizona Cardinals wide receiver Anquan Boldin suffered a high ankle sprain last week against the Seahawks but will he suit up against the New York Giants? (AP Photo/Paul Connors)

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With Wednesday's being the big practice day of the NFL week and the first release of an injury report it's always interesting to see who's name pops up on the list. For the Arizona Cardinals the injury situation is pretty clear. Anquan Boldin has a high ankle sprain and didn't practice at all, although he and Ken Whisenhunt said that they were encouraged by his progress. Boldin told reporters after practice that he thought he'd be a 'game time decision' which doesn't sound promising considering that he normally overly optimistic early in the week. Stephen Spach is the only other player who missed practice entirely but with the return of Ben Patrick, Spach's absence is less of an issue. Steven Breaston (knee) and Beanie Wells (hip) were both limited in practice but neither of them are in jeopardy of missing the game.

For the Giants the injury situation is a much bleaker picture. Michael Boley, Chris Canty and Aaron Ross are all starters who missed practice and are not expected to suit up on Sunday. With this trio being out coupled with the loss of Kenny Phillips earlier in the year, the Giants defense is missing four starters. The Giants had several other players who were limited, including starters Eli Manning, Antonio Pierce, Kareem McKenzie, but none of them are in jeopardy of missing the game.

The big question for the Cardinals will be what to do if Boldin can't play. Will Early Doucet see his first significant action of the season? Will the game plan change to a more conservative approach? Will Breaston still return punts if he's the #2 wide out?