Start: Colin Kaepernick
The Niners have unleashed Kaepernick as a runner and with a favorable matchup against the Jags I would wager he is in the Top 3 in scoring this weekend.
Sit: Tom Brady
Start: Fred Jackson
No CJ Spiller this weekend suggests an enhanced role for Jackson in the Bills offense, who are becoming a run-first team.
Sit: Maurice Jones-Drew
Combine a very tough matchup against the physical 49ers defense, the fact that MJD has not been productive all year and that the Jags will be behind a lot which means they'll pass more doesn't bode well for a good fantasy outing.
Start: Larry Fitzgerald
Atlanta have allowed 14 passing TDs so far this season and have one if the worst secondaries in the league. Hopefully Carson Palmer can capitalize on this matchup.
Sit: Dwayne Bowe
Start: Jordan Reed
Sit: Jordan Cameron
Seeing decreased targets since Brian Hoyer went down, Cameron's value is falling. With Jason Campbell now quarterbacking the Browns, Cameron will be held to small production against the best defense in football, some might say.