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Read on for our picks.
Baltimore Ravens (-6.5) at Seattle Seahawks: Fresh off of a victory over their hated rivals, this game against a weak Seahawks team could be a trap game on the road, where Seattle traditionally plays much better. But Seattle is 0-3 against the AFC this season. Tarvaris Jackson is still not 100 percent with his pectoral injury, but fully practiced as of Thursday. Pick: Ravens, -6.5.
Detroit Lions at Chicago Bears (-2.5): The Bears offensive line did not allow a sack against the Eagles and Matt Forte continues to roll. In the last meeting between these two teams, Jahvid Best gashed the Bears defense for 163 yards. Best is not expected to play, as he is still recovering from a concussion. The Chicago defense will not allow a season sweep. Pick: Bears, -2.5.
New York Giants at San Francisco 49ers (-3.5): The Giants had a great win over the Patriots, but they are a tough team to trust. They barely held off the Miami Dolphins and essentially stole a win from the Cardinals. The Niners have very methodical at their game, running the ball, stopping people and putting Alex Smith in situations in which he can succeed. However, Eli Manning is the best QB they have faced all year and the Giants pass rush is dangerous. This will be the week that the Niners slip. Pick: Giants, +3.5.
New England Patriots at New York Jets (-1.5): The Jets have won three straight and are 4-0 at home. The Patriots have lost two straight. This is a bad combination for the Jets. The New England defense is not very good, but Mark Sanchez isn't either. With the game on Sunday Night Football, expect to see a Tom Brady with a chip on his shoulder. Pick: Patriots, +1.5.
Minnesota Vikings at Green Bay Packers (-13.5): The NFL must have thought that Brett Favre was going to return for the 2011 season when they scheduled this game. The only people who will enjoy this game are Packers fans. The Vikings have yet to win in their division, and it will be a tall task to do against the best team in football. Green Bay is beating teams by an average of over 10 points a game. Beating a bad team by 14 should not be too tough a task. Pick: Packers, -13.5