NFL picks against the spread Week 5: Peyton Manning won't beat Tom Brady

We already gave our early Sunday picks and said that the Eagles and the Browns were the upset picks of the early games. What of the later Sunday games? Our picks are below.

Seattle Seahawks at Carolina Panthers (-3): Both Carolina and Seattle coming off of tough losses, but the key here is Seattle's defense. Cam Newton is struggling and so is Seattle's Russell Wilson, but Seattle can lean on Marshawn Lynch and its defense. The NFC West is strong. This game will show it yet again. Pick: Seahawks, +3.

Chicago Bears (-6) at Jacksonville Jaguars: Chicago is rolling ever since Jay Cutler went berserk on Monday Night Football. Expect it to continue. Pick: Bears, -6.

Tennessee Titans at Minnesota Vikings (-6): it's time to stop doubting Minnesota and at the same time stop expecting anything from the Titans. Chris Johnson isn't going to do much, while Adrian Peterson is having a superb year. Pick: Vikings, -6.

Denver Broncos at New England Patriots (-7): Peyton Manning and the Broncos are not coming to Foxboro at the right time. Tom Brady found a groove with his offense and will be fired up to beat Peyton, as all offseason was about him and not Mr. Brady. Pick: Pats, -7 (it's going to be a blowout).

Buffalo Bills at San Francisco 49ers (-10): San Fran is rolling after a 34-0 win over the New York Jets. Buffalo has only beaten Cleveland and Kansas City and got steamrolled last week by the Patriots. They are going to have a hard time recovering and the Niners will have their stout rush defense to stifle the Buffalo running game. Pick: Niners, -10.

San Diego Chargers at New Orleans Saints (-4): You get the feeling that the Saints are going to break through soon. At home on national television is about the way to do it. San Diego is not going to be ready. Pick: Saints, -4.