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NFL picks against the spread: Andrew Luck on a Thursday night for the win and cover

A pair of young signal callers face off on NFL Network in an AFC South battle

Thomas J. Russo-US PRESSWIRE

On this Thursday night game between the Indianapolis Colts and the Jacksonville Jaguars, the story is about the two young quarterbacks that lead their team. One was much maligned a year ago and has made some great strides this year (the Jags' Blaine Gabbert) and the other has been lighting things up (the Colts' Andrew Luck).

The Colts head into Jacksonville as road favorites, with the line at -4 for them. Luck is coming off of a record-setting performance, throwing for 433 yards, most of which were on deep balls.

While the trend for the Thursday night game has been to favor the home team, you have to look at the Jags as hopeless. They look terrible defensively and are 0-4 at home on the season. Combine that with a Colts team that is starting to show life with all the young talent hey have and you have to like Indy in this one.

Pick: a no-brainer...Colts, -4.