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Cardinals vs. Lions final score: Arizona uses turnovers, 28 2nd-quarter points to roll over Detroit 42-17

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Arizona bounces back nicely on the road.

Raj Mehta-USA TODAY Sports

The Arizona Cardinals, facing a winless Detroit Lions team in Week 5, took care of business and gained a game in the NFC West. Behind four first half Lions turnovers and 28 second quarter points, Arizona rolled to a 42-17 win over the Lions Sunday afternoon.

Arizona's offense struggled in the first quarter, failing to take advantage of a pair of turnovers by Detroit. Rashad Johnson picked off a Matthew Stafford pass and Tony Jefferson forced a fumble, but the Lions forced a pair of three-and-outs.

Stafford got the offense going first, taking Detroit down the field and finding Theo Riddick for a six-yard touchdown.

But the Cardinals answer. A 25-yard run by Chris Johnson and a facemask penalty sparked the Cardinals and Carson Palmer found Darren Fells for a touchdown pass.

Then Cory Redding intercepted Stafford and returned it inside the five. David Johnson scored on the very next play, rushing four yards to give the Cardinals a 14-7 lead.

Arizona made it 21-7 with a 99-yard drive in five plays. After the Lions pinned them inside the one with a brilliant punt by Sam Martin, Palmer finds John Brown on a deep throw and Chris Johnson gets a 40-yard run before David Johnson punched it in from two yards out.

Detroit managed to turn it over again -- and the Cardinals scored another touchdown, only this time John Brown got the pass from Palmer.

Four turnovers, 28 points in the second quarter. That was all they needed.

Arizona would turn a Patrick Peterson interception into a Larry Fitzgerald touchdown. Then Dan Orlovsky would then come in to play quarterback for the Lions. He would lead them to a fourth quarter field goal.

Carson Palmer got the final 12 minutes off, as Drew Stanton relieved him the rest of the way. Palmer finished 11/14 for 161 yards and three touchdowns. His passer rating was nearly perfect -- 154.2.

After Stanton entered the game, Chris Johnson reached 100 rushing yards and then Andre Ellington took the very next play 63 yards for a score.

Stanton was 1/4 for 10 yards.

John Brown led the team in receiving with four catches for 73 yards and a touchdown. Larry Fitzgerald had five for 58 and a score.

In the running game, Chris Johnson led the way with 11 carries for 103 yards, but David Johnson and Andre Ellington combined for three touchdowns.

For Detroit, Stafford left the game 20/32 for 188 yards, one touchdown and three picks. Detroit was held to 57 rushing yards, coming a week after giving up 146 to Todd Gurley. Calvin Johnson had five catches for 67 yards.

With the Seahawks and the Rams both losing, Arizona extends their lead in the NFC West.

Next up for the Cardinals are the Pittsburgh Steelers and they will stay in West Virginia this week to avoid traveling back and forth.