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Arizona Cardinals lose Tony Jefferson and Calais Campbell to free agency

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It is over for the Arizona Cardinals and two of their top defensive players.

NFL: Preseason-Oakland Raiders at Arizona Cardinals Mark J. Rebilas-USA TODAY Sports

We all knew this day was coming, it was just a matter of when, not if.

That day is today, as the Arizona Cardinals are supposed to be losing two of their top defensive players in free agency according to a number of ESPN reports.

This is not unexpected, but it is one of those situations where you just wonder what is next for the Arizona Cardinals.

They will need to find a way to replace the production of the best 3-4 defensive end in the NFL in Calais Campbell, with Rodney Gunter and Robert Nkemdiche.

At safety, there is an even bigger question mark now, with Tyvon Branch and Tyrann Mathieu the only safeties on the roster, unless they keep Harlan Miller at safety.

They have a lot of work to do in terms of finding talent to fill needs, whether that is on their roster, in free agency or in the draft in 2017, but it will be fun to see what happens.