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Robert Nkemdiche to make season debut, Mike Iupati, John Brown to miss game against Indianapolis Colts

The Arizona Cardinals injury report is out for the Colts game.

Oakland Raiders v Arizona Cardinals Photo by Christian Petersen/Getty Images

The Arizona Cardinals will look a big different on offense when they start game two of the regular season.

Four starters from game one:

David Johnson

D.J. Humphries

Mike Iupati

John Brown

Will not play on Sunday against the Colts.

In their place comes Kerwynn Williams, John Wetzel, newly acquired Alex Boone and Jaron Brown.

In addition to the new starters, young players Elijhaa Penny and Chad Williams are likely to get work on Sunday.

Maybe the best news to come out of Bruce Arians press conference is that Robert Nkemdiche will make his season debut against the Indianapolis Colts.

Also, there is a chance that $LB Deone Bucannon will get on the field as well.

It has been a rough beginning to the season for the Cardinals, even before the cavalcade of injuries beset the team, now going into week two, with maybe their season on the line, only 8% of teams make the playoffs after starting 0-2, they'll be without four expected starters.

It'll be Carson Palmer and Bruce Arians rising to the occasion and formulating a plan to get the offense going despite all the injuries.