It is the first taste of the Pacific Northwest for the Kyler Murray and Kliff Kingsbury show and things are a bit different.
Gone is the Legion of Boom and in its place is a different type of defense.
The Cardinals will need to find a way to get their offense humming, something they could not do in their first meeting.
This time, they have to do it in Seattle.
Here is everything you need to know about the game today.
Who: Arizona Cardinals (4-9-1) at Seattle Seahawks (11-3)
Where: CenturyLink Field — Seattle, Washington
When: December 22, 2019 - 2:25 p.m. Arizona Time
TV: Fox (Local Channel 10) - Chris Myers (Play-by-Play) Daryl Johnston (Color Analyst) Laura Okmin (Sideline Reporter)
Local Radio: Arizona Sports 98.7 FM - Dave Pasch (Play-by-Play) Ron Wolfley (Color Analyst) Paul Calvisi (Sideline Reporter)
Spanish Radio: TUDN Phoenix 105.1 FM - Gabriel Trujillo (Play-by-Play) Rolando Cantu (Color Analyst)
Odds: Cardinals +9.5