It should be interesting to see how this one plays out, as the 49ers offense still has not fully clicked and they are dealing with injuries on defense.
Here is everything you need to know about tonight’s game.
- Game: San Francisco 49ers (5-4) at Arizona Cardinals (4-6)
- Start Time: 6:15 pm Arizona time on November 21, 2022
- Location: Estadio Azteca - Mexico City, Mexico
- TV Channel: ESPN
- Announcers: Joe Buck (play-by-play), Troy Aikman (analyst), Lisa Salters (sideline)
- Streaming: ESPN+
- Alternative TV: ESPN2 will once again provide the ManningCast with Peyton and Eli Manning discussing the game
- National Radio: Westwood One | Ryan Radtke (play-by-play) and Mike Golic (analyst)
- Odds: Cardinals +8 per our friends at DraftKings Sportsbook
- Over/Under: 43