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Arizona Cardinals open as massive home underdogs against surging San Francisco 49ers

The Arizona Cardinals are big home underdogs ahead of their matchup with the San Francisco 49ers.

NFL: Arizona Cardinals at San Francisco 49ers Cary Edmondson-USA TODAY Sports

The Arizona Cardinals are coming off their third win of the 2023 NFL season against a then 7-4 Pittsburgh Steelers.

Now, the Steelers sit at 7-6 and have lost games decisively against the Cardinals and the terrible New England Patriots as well.

So, when the opening lines came out for the Arizona Cardinals against the San Francisco 49ers, it was not shocking to see that DraftKings Sportsbook had the 49ers as massive favorites, even though the game is at home.

The Cardinals opened as +13.5-point underdogs for this one.

This is a massive line, but it makes sense based on what the two teams have done the last five games.

While the Cardinals are 2-3, including 2-2 with Kyler Murray, the 49ers are 5-0 and their games have looked like this:

49ers - 34
Jaguars -3

49ers - 27
Buccaneers - 14

49ers - 31
Seahawks - 13

49ers - 42
Eagles - 19

49ers - 28
Seahawks - 16

That means against four teams with winning records and the Bucs, they have won by at least 12.

It will take their best effort of the season for the Cardinals to cover that line, but what do you think?